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I’m Jo, a British anaesthetist/intensivist working in the Cotswolds. I flirt a lot with academic ICM/physiology and pretty passionate about mitochondria…

Mostly post latest research/random evolutionary facts about dinosaurs and bleeding, and argue about defining ARDS.

Otherwise it’s pictures of the wild outdoors, my vizsla or new mitochondrial project (baby!)
Intrigued to see what happens…

as the institutionalization of

: “new scientific institutes and universities… created in every city a culture that encourage scientists to look for new problems, to solve them through experiment and teamwork, and to train the next generation of discontented experts”

I love the phrase

nights are brutal. So.much.superinfection.😔☠️😔
Yes FluA is terrible but also the most vicious Strep I have ever seen in my career, and I predate routine Strep vaccines.
Unremitting.
Exhausting.
Ugh.

Never seen a respiratory season like this. Makes you wonder about all the “asymptomatic” COVID in kids - did it interfere with their innate immunity somehow?
Or maybe flu is particularly vicious this year. 🤷‍♀️

I was today years old when I learned that Louis Pasteur referred to the filiform microbe B. anthracis as "vibrions baguettes."

Bacterial breadsticks!

(I know that "baguette" in French is used in a number of contexts beyond the baker's oven, but allow me my moment's chuckle.)

Love this as highlighted to me by the Birmingham icu folks - peri op role for severe AKI prediction? TIMP2*IGFBP7 is point of care with good AUROC for select groups - help with post op admission bed management? pubmed.ncbi.nlm.nih.gov/356048

Great AKI review: new bits are the importance of crosstalk (eg Galectin 3 in cardiac damage) and mitochondrial dysfunction (need PGC1a and NAD+), clinically approved bio markers for severe AKI <12 hours NGAL and TIMP2*IGFBP7 but no evidence for early RRT and contrast injury is associated not causal - bicarb/NAC no better than placebo

link.springer.com/article/10.1

Congrats to Sarah Wahlster for leading an important effort to describe neurologic prognostication practices after OHCA in our region.

link.springer.com/article/10.1

TLDR: Lots of variation and too much early WLST. Local guidelines should encourage best practices in this space.

There are sixteen sunsets and sunrises on the international space station. Mission control calibrates via GMT each morning as mutually inconvenient between Moscow and US

to new instance!
I'm an end stage trainee working in Trondheim, Norway, finishing up a PhD in in stroke care, aiming to subspecialise in and . Obsessed with , fascinated by and , concerned about the future of our system, and
Toots in English, Norwegian, Danish and French.

First post might as well be a one

My latest talk and discussion in Torino, Italy (sadly just virtual)

bit.ly/3hN1EGJ

Get space induced ileus. Thorax expands slightly. Cerebral function - increased cerebral pressure - huge new wonderful distractions - have to figure out how to put down a coffee or pencil…space is really hard on the eyes - things fly into them all the time

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Nobody would pass sobriety test as eyesight and vestibular system rewire whilst in space. So much interest in space medicine and tourism and science - a rush this year.

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Landing 4G force on re entering atmosphere, 5000 degrees Celsius, “two explosions followed by a car crash”, bits of heat shield breaking off…

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Sepsis kidney stones arrhythmia burns inhalational injury dental problems back pain

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“Honour but not a pleasure” to spacewalk…like a bar fight?? He did 350 experiments whilst up there in space. Restricted medical resources. BP low in space. HR low. Until workout when higher than expected. Drugs might not work as expected in space.

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